TRF2 Monoclonal Antibody (Clone 4A794.15)_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

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Cat. Number

068728593478275

Chemical Name

TRF2 Monoclonal Antibody (Clone 4A794.15)

References

Synonyms

TERF2
Telomeric Repeat Binding Factor 2
TRBF2
TTAGGG Repeat Binding Factor 2

Formulation

100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Human TRF2	+
Murine TRF2	+
Muntjac TRF2	+
Rat TRF2	+

Show all 4 Hide all but first 3

Background Reading

Karlseder, J., Broccoli, D., Dai, Y., et al. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283(5406) 1321-1325 (1999).

van Steensel, B., Smogorzewska, A., and de Lange, T. TRF2 protects human telomeres from end-to-end fusions. Cell 92 401-413 (1998).

Broccoli, D., Smogorzewska, A., Chong, L., et al. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet 17 231-235 (1997).

Size	Global Purchasing
1 ea

Description

Antigen: Full length human TRF2 · Clone designation: 4A794.15 · Host: Mouse · Isotype: IgG1κ · Application(s): FC, ICC, and WB · Telomeric repeat binding factor (TRF2) is a ubiquitously expressed protein that is implicated in the control of telomere length.¹ TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes.¹ TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini.² The use of mutant forms of TRF2 has implicated a role of TRF2 in the prevention of senescence in primary human cells.² Inhibition of TRF2 results in apoptosis in a subset of mammalian cell types.³

1 Broccoli, D., Smogorzewska, A., Chong, L., et al. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet 17 231-235 (1997).

2 van Steensel, B., Smogorzewska, A., and de Lange, T. TRF2 protects human telomeres from end-to-end fusions. Cell 92 401-413 (1998).

3 Karlseder, J., Broccoli, D., Dai, Y., et al. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283(5406) 1321-1325 (1999).

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