| References |
| Synonyms |
- TTAGGG Repeat Binding Factor 2
- TRBF2
- Telomeric Repeat Binding Factor 2
- TERF2
|
| Formulation |
100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| Specificity |
| Human TRF2 |
+ |
| Murine TRF2 |
+ |
|
Background Reading
Broccoli, D., Smogorzewska, A., Chong, L., et al. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet 17 231-235 (1997).
van Steensel, B., Smogorzewska, A., and de Lange, T. TRF2 protects human telomeres from end-to-end fusions. Cell 92 401-413 (1998).
Karlseder, J., Broccoli, D., Dai, Y., et al. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283(5406) 1321-1325 (1999).
| Size |
Global Purchasing |
| 1 ea |
|
Description
Antigen:
full length human TRF2
·
Host:
Goat
·
Application(s):
ChIP, ICC, IP, and WB
·
Telomeric repeat binding factor (TRF2) is a ubiquitously expressed protein that is implicated in the control of telomere length.1 TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes.1 TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini.2 The use of mutant forms of TRF2 has implicated a role of TRF2 in the prevention of senescence in primary human cells.2 Inhibition of TRF2 results in apoptosis in a subset of mammalian cell types.3
1
Broccoli, D., Smogorzewska, A., Chong, L., et al. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet 17 231-235 (1997).
2
van Steensel, B., Smogorzewska, A., and de Lange, T. TRF2 protects human telomeres from end-to-end fusions. Cell 92 401-413 (1998).
3
Karlseder, J., Broccoli, D., Dai, Y., et al. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283(5406) 1321-1325 (1999).
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