| References |
| Synonyms |
- Anti-Phospho-Ser33,37 β-Catenin
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| Formulation |
Affinity-purified IgG |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| Specificity |
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Background Reading
Ding, Y., and Dale, T. Wnt signal transduction: Kinase cogs in a nano-machine? Trends Biochem Sci 27 327-329 (2002).
Liu, C., Li, Y., Semenov, M., et al. Control of b-catenin phosphorylation/degradation by a dual-kinase mechanism.. Cell 108 837-847 (2002).
Wang, Z.H., Vogelstein, B., and Kinzler, K.W. Phosphorylation of b-catenin at S33, S37, or T41 can occur in the absense of phosphorylation at T45 in colon cancer cells.. Cancer Res 63 5234-5235 (2003).
Polakis, P. Wnt signaling and cancer.. Genes Dev 14 1837-1851 (2000).
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| Size |
Global Purchasing |
| 1 ea |
|
Description
Antigen:
phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser33,37 of human β-catenin
·
Host:
rabbit
·
Application(s):
WB
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β-Catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway.1,2 The role of β-catenin in these processes is thought to be regulated by the sequential phosphorylation of Ser29, Ser33, Ser37, and Thr41 by glycogen synthase kinase 3β (GSK3β).3 This hyperphosphorylation promotes the ubiquitylation and targeted destruction of β-catenin. Mutations in components of this phosphorylation-regulated process that prevent β-catenin hyperphosphorylation by GSK3β are strongly associated with cancers.3,2,4
1
Ding, Y., and Dale, T. Wnt signal transduction: Kinase cogs in a nano-machine? Trends Biochem Sci 27 327-329 (2002).
2
Polakis, P. Wnt signaling and cancer.. Genes Dev 14 1837-1851 (2000).
3
Liu, C., Li, Y., Semenov, M., et al. Control of b-catenin phosphorylation/degradation by a dual-kinase mechanism.. Cell 108 837-847 (2002).
4
Wang, Z.H., Vogelstein, B., and Kinzler, K.W. Phosphorylation of b-catenin at S33, S37, or T41 can occur in the absense of phosphorylation at T45 in colon cancer cells.. Cancer Res 63 5234-5235 (2003).
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