| References |
| Formulation |
Peptide affinity-purified IgG |
| Stability |
6 months |
| Storage |
4°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
Background Reading
Su, L., Vogelstein, B., and Kinzler, K.W. Association of the APC tumor suppressor protein with catenins. Science 262 1734-1737 (1993).
Chenn, A., and Walsh, C.A. Increased neuronal production, englarged forebrains and cytoachitectural distortions in β-catenin overexpressing transgenic mice. Cereb Cortex 13 599-606 (2003).
Chung, S.S.W., Lee, W.M., and Cheng, C.Y. Study on the formation of specialized inter-sertoli cell junctions in vitro. J Cell Physiol 181 258-272 (1999).
Jaiswell, A.S., Marlow, B.P., Gupta, N., et al. β-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. Oncogene 21 8414-8427 (2002).
Yano, H., Hara, A., Takenaka, K., et al. Differential expression of β-catenin in human glioblastoma multiforme and normal brain tissue. Neurol Res 22 650-656 (2000).
Aberle, H., Butz, S., Stappert, J., et al. Assembly of the cadherin-catenin complex in vitro with recombinant proteins. J Cell Sci 107 3655-3663 (1994).
Olmeda, D., Castel, S., Vilaró, S., et al. β-catenin regulation during the cell cycle: Implications in G2/M and apoptosis. Mol Biol Cell 14 2844-2860 (2003).
Haq, S., Michael, A., Andreucci, M., et al. Stabilization of β-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth. Proc Natl Acad Sci USA 100(8) 4610-4615 (2003).
Yasui, K., Li, G., Wang, Y., et al. β-Catenin in early development of the lancelet embryo indicates specific determination of embroyonic polarity. Dev Growth Differ 44 467-475 (2002).
Nollet, F., Berx, G., Molemans, F., et al. Genomic organization of the human β-catenin gene (CTNNB1). Genomics 32 413-424 (1996).
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| Size |
Global Purchasing |
| 500 µl |
|
Description
Antigen:
human β-catenin amino acids 43-62 (APSLSGKGNPEEEDVDTSQV)
·
Host:
rabbit
·
Application(s):
WB and IHC
·
β-Catenin is a multifunctional protein known to be part of the Wnt pathway, playing essential roles in development and carcinogenesis.1,2,3 β-Catenin can act as a regulator of the cell cycle and apoptosis in a variety of different cell systems.4,5 The entire primary amino acid sequence is identical among human, rat, and mouse, indicating critical functions of this protein6,7,8. Cayman Chemical’s β-catenin polyclonal antibody can be used for Western blot and immunohistochemical (formalin-fixed paraffin-embedded tissue) analysis of β-catenin on samples of human, murine, rat, porcine and bovine origin. Use of this antibody for other species and applications has not yet been tested.
1
Yano, H., Hara, A., Takenaka, K., et al. Differential expression of β-catenin in human glioblastoma multiforme and normal brain tissue. Neurol Res 22 650-656 (2000).
2
Haq, S., Michael, A., Andreucci, M., et al. Stabilization of β-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth. Proc Natl Acad Sci USA 100(8) 4610-4615 (2003).
3
Yasui, K., Li, G., Wang, Y., et al. β-Catenin in early development of the lancelet embryo indicates specific determination of embroyonic polarity. Dev Growth Differ 44 467-475 (2002).
4
Olmeda, D., Castel, S., Vilaró, S., et al. β-catenin regulation during the cell cycle: Implications in G2/M and apoptosis. Mol Biol Cell 14 2844-2860 (2003).
5
Jaiswell, A.S., Marlow, B.P., Gupta, N., et al. β-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. Oncogene 21 8414-8427 (2002).
6
Aberle, H., Butz, S., Stappert, J., et al. Assembly of the cadherin-catenin complex in vitro with recombinant proteins. J Cell Sci 107 3655-3663 (1994).
7
Chung, S.S.W., Lee, W.M., and Cheng, C.Y. Study on the formation of specialized inter-sertoli cell junctions in vitro. J Cell Physiol 181 258-272 (1999).
8
Nollet, F., Berx, G., Molemans, F., et al. Genomic organization of the human β-catenin gene (CTNNB1). Genomics 32 413-424 (1996).
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