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Cat. Number

065894236268844

Chemical Name

Prostaglandin D Synthase Inhibitor Screening Assay Kit

References

Synonyms

PGDS Inhibitor Screening Assay Kit

Stability

6 months

Storage

-80°C

Shipping

Dry ice in continental US; may vary elsewhere

Specificity

Prostaglandin D2 Ethanolamide	3,000%
Prostaglandin F2α	300%
Prostaglandin D2	100%
Prostaglandin J2	17%
11β-Prostaglandin F2α	10.7%
Thromboxane B2	10%
Prostaglandin D1	1%
Prostaglandin D3	1%
Prostaglandin E2	1%
8-iso Prostaglandin F2α	1%
6-keto Prostaglandin F1α	0.6%
2,3-dinor 11β-Prostaglandin F2α	0.2%
12(S)-HHTrE	0.14%
Δ12-Prostaglandin J2	0.07%
Arachidonic Acid	<0.01%
tetranor-PGEM	<0.01%
tetranor-PGFM	<0.01%
13,14-dihydro-15-keto Prostaglandin D2	<0.01%
15-deoxy-Δ12,14-Prostaglandin J2	<0.01%

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Background Reading

Urade, Y., Watanabe, K., and Hayaishi, O. Prostaglandin D, E, and F synthases. J Lipid Mediat Cell Signal 12 257-273 (1995).

Kanaoka, Y., Fujimori, K., Kikuno, R., et al. Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Eur J Biochem 267 3315-3322 (2000).

Kanaoka, Y., Ago, H., Inagaki, E., et al. Cloning and crystal structure of hematopoietic prostaglandin D synthase. Cell 90 1085-1095 (1997).

Urade, Y., Fujimoto, N., Ujihara, M., et al. Biochemical and immunological characterization of rat spleen prostaglandin D synthetase. J Biol Chem 262(8) 3820-3825 (1987).

Jowsey, I.R., Thomson, A.M., Flanagan, J.U., et al. Mammalian class sigma glutathione s-transferases: Catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D₂ synthases. Biochem J 359 507-516 (2001).

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10006595-96WELL
PGDS Screening Assay Prostaglandin D Synthase (hematopoietic-type)	1 ea
PGDS Screening Assay Prostaglandin D Synthase (lipocalin-type)	1 ea
PGDS Screening Assay Glutathione	1 ea
PGDS Screening Assay Dithiothreitol	1 ea
PGDS Screening Assay Prostaglandin H2	1 ea
PGDS Screening Assay Hydrochloric Acid	1 ea
PGDS Screening Assay Iron (II) Chloride	1 ea
PGDS Screening Assay Reaction Buffer	1 ea
Precoated (Goat Anti-Mouse IgG) EIA 96-Well Strip Plate	1 ea
Polysorbate 20	1 ea
Ellman's Reagent	3 × 100 dtn
EIA Buffer Concentrate (10X)	2 × 10 mL
Wash Buffer Concentrate (400X)	5 mL
Prostaglandin D2 Express AChE Tracer	100 dtn
Prostaglandin D2 Express EIA Monoclonal Antibody	100 dtn
Prostaglandin D2 Express EIA Standard	1 ea

Size	Global Purchasing
96 wells

Description

Prostaglandin D₂ (PGD₂) is synthesized by two distinct types of prostaglandin D synthase (PGDS), the lipocalin-type (L-PGDS) enzyme and the hematopoietic (H-PGDS) enzyme. PGD₂ is produced by H-PGDS in large quantities by allergen-stimulated mast cells and acts as a pro-inflammatory mediator in allergic reactions. Selective inhibition of H-PGDS is therefore being pursued as a drug target for allergy treatment. The Cayman Chemical PGDS Inhibitor Screening Assay Kit is a complete package for the evaluation of PGDS isozyme-specific inhibitors. Each kit includes highly purified H-PGDS and L-PGDS, as well as PGH₂ which serves as the enzyme substrate. A complete enzyme immunoassay (EIA) for the direct quantification of PGD₂ quantification without prior methoximation is included in the kit.

下一个：Prostaglandin D Synthase (hematopoietic-type; human recombinant)上一个：Renin Inhibitor Screening Assay Kit

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