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021-60498804
| Cat. Number | 065859998070516 |
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| Chemical Name | Sphingomyelinase Inhibitor Screening Assay Kit |
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| References |
Background ReadingClarke, C.J., Snook, C.F., Tani, M., et al. The extended family of neutral sphingomyelinases. Biochemistry 45(38) 11247-11256 (2006). Hannun, Y.A., and Obeid, L.M. The ceramide- Tabas, I., Li, Y., Brocia, R.W., et al. Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix: A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation. J Biol Chem 268(27) 20419-20432 (1993). Pörn, M.I., and Slotte, J.P. Localization of cholesterol in sphingomyelinase- Kolesnick, R. The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J Clin Invest 110(1) 3-8 (2002). Kornhuber, J., Medlin, A., Bleich, S., et al. High activity of acid sphingomyelinase in major depression. J Neural Transm 112 1583-1590 (2005). Wascholowski, V., and Giannis, A. Neutral sphingomyelinase as a target for drug design. Drug News Perspect 14(10) 581-590 (2001). Kolesnick, R.N. Sphingomyelin and derivatives as cellular signals. Prog Lipid Res 30(1) 1-38 (1991). Smith, E.L., and Schuchman, E.H. The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases. FASEB J 22 3419-3431 (2008). Gulbins, E., and Li, P.L. Physiological and pathophysiological aspects of ceramide. Am J Physiol Regul Integr Comp Physiol 290 R11-R26 (2006). Hakogi, T., Fujii, S., Morita, M., et al. Synthesis of sphingomyelin sulfur analogue and its behavior toward sphingomyelinase. Bioorg Med Chem Lett 15 2141-2144 (2005). Luberto, C., Hassler, D.F., Signorelli, P., et al. Inhibition of tumor necrosis factor-
Description
Sphingomyelinase (SMase) is a hydrolase enzyme that is involved in sphingolipid metabolism. SMase is a member of the DNase I superfamily of enzymes and is responsible for the breakdown of sphingomyelin into phosphocholine and ceramide. The activation of SMase has been suggested as a major route for the production of ceramide in response to cellular stress.1 SMases are important in many physiological and pathophysiological processes, including: 1. lysosomal digestion of sphingomyelin, which is important for normal neuronal and vascular function; 2. ceramide-
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Hannun, Y.A., and Obeid, L.M. The ceramide- 2 Kolesnick, R.N. Sphingomyelin and derivatives as cellular signals. Prog Lipid Res 30(1) 1-38 (1991). 3 Tabas, I., Li, Y., Brocia, R.W., et al. Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix: A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation. J Biol Chem 268(27) 20419-20432 (1993).
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Pörn, M.I., and Slotte, J.P. Localization of cholesterol in sphingomyelinase- 5 Smith, E.L., and Schuchman, E.H. The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases. FASEB J 22 3419-3431 (2008). 6 Gulbins, E., and Li, P.L. Physiological and pathophysiological aspects of ceramide. Am J Physiol Regul Integr Comp Physiol 290 R11-R26 (2006). 7 Kolesnick, R. The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J Clin Invest 110(1) 3-8 (2002). 8 Kornhuber, J., Medlin, A., Bleich, S., et al. High activity of acid sphingomyelinase in major depression. J Neural Transm 112 1583-1590 (2005). 9 Wascholowski, V., and Giannis, A. Neutral sphingomyelinase as a target for drug design. Drug News Perspect 14(10) 581-590 (2001). 10 Clarke, C.J., Snook, C.F., Tani, M., et al. The extended family of neutral sphingomyelinases. Biochemistry 45(38) 11247-11256 (2006).
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Luberto, C., Hassler, D.F., Signorelli, P., et al. Inhibition of tumor necrosis factor- 12 Hakogi, T., Fujii, S., Morita, M., et al. Synthesis of sphingomyelin sulfur analogue and its behavior toward sphingomyelinase. Bioorg Med Chem Lett 15 2141-2144 (2005). |
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