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Cat. Number

653049982568420

Chemical Name

Leukotriene C4 Lipid Maps MS Standard

References

Synonyms	LTC4
CAS Number	72025-60-6
Molecular Formula	C₃₀H₄₇N₃O₉S
Formula Weight	625.8
Formulation	A solution in ethanol:water (95:5)
Purity	>97%
Stability	1 year
Storage	-80°C
Shipping	Dry ice in continental US; may vary elsewhere
SMILES	CCCCC/C=CC/C=C/C=CC=C/C(SCC(N)(C(=O)NCC(=O)O)N1C(=O)CCC1C(=O)O)[C@@H](O)CCCC(=O)O

Background Reading

Piper, P.J. Formation and actions of leukotrienes. Physiol Rev 64 744-761 (1984).

Lefer, A.M. Leukotrienes as mediators of ischemia and shock. Biochem Pharmacol 35 123-127 (1986).

Maclouf, J.A., and Murphy, R.C. Transcellular metabolism of neutrophil-derived leukotriene A₄ by human platelets. A potential cellular source of leukotriene C₄. J Biol Chem 263 174-181 (1988).

Samuelsson, B. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation. Science 220 568-575 (1983).

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Size	Global Purchasing
25 µg
50 µg
100 µg
500 µg

Description

Leukotriene C₄ (LTC₄) is the parent cysteinyl leukotriene produced by the LTC₄ synthase catalyzed conjugation of glutathione to LTA₄. LTC₄ is produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets.¹ It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity.² LTC₄-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity.^3,4 The concentration of LTC₄ required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM.⁴

1 Maclouf, J.A., and Murphy, R.C. Transcellular metabolism of neutrophil-derived leukotriene A₄ by human platelets. A potential cellular source of leukotriene C₄. J Biol Chem 263 174-181 (1988).

2 Piper, P.J. Formation and actions of leukotrienes. Physiol Rev 64 744-761 (1984).

3 Samuelsson, B. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation. Science 220 568-575 (1983).

4 Lefer, A.M. Leukotrienes as mediators of ischemia and shock. Biochem Pharmacol 35 123-127 (1986).

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