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Cat. Number

653026475461085

Chemical Name

Leukotriene B4 Lipid Maps MS Standard

References

Synonyms	LTB4
Formal Name	5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid
CAS Number	71160-24-2
Molecular Formula	C₂₀H₃₂O₄
Formula Weight	336.5
Formulation	A solution in ethanol
Purity	≥97%
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	CCCCC/C=CC[C@@H](O)/C=C/C=CC=C[C@@H](O)CCCC(=O)O

Background Reading

Ford-Hutchinson, A.W. Leukotriene B₄ in inflammation. Crit Rev Immunol 10 1-12 (1990).

Rådmark, O., Malmsten, C., Samuelsson, B., et al. Leukotriene A: Stereochemistry and enzymatic conversion to leukotriene B. Biochem Biophys Res Commun 92 954-961 (1980).

Ford-Hutchinson, A.W., Bray, M.A., Doig, M.V., et al. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286 264-265 (1980).

McMillan, R.M., and Foster, S.J. Leukotriene B₄ and inflammatory disease. Agents Actions 24 114-119 (1988).

McGee, J., and Fitzpatrick, F. Enzymatic hydration of leukotriene A₄. J Biol Chem 260 12832-12837 (1985).

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Size	Global Purchasing
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Description

Leukotriene B₄ (LTB₄) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway.^1,2,3 It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10⁻¹⁰ M), LTB₄ causes chemotaxis and chemokinesis in human polymorphonuclear leukocytes.⁴ At higher concentrations, (1.0 x 10⁻⁷ M), LTB₄ leads to neutrophil aggregation and degranulation as well as superoxide anion production.^4,5

1 Rådmark, O., Malmsten, C., Samuelsson, B., et al. Leukotriene A: Stereochemistry and enzymatic conversion to leukotriene B. Biochem Biophys Res Commun 92 954-961 (1980).

2 Ford-Hutchinson, A.W., Bray, M.A., Doig, M.V., et al. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286 264-265 (1980).

3 McGee, J., and Fitzpatrick, F. Enzymatic hydration of leukotriene A₄. J Biol Chem 260 12832-12837 (1985).

4 Ford-Hutchinson, A.W. Leukotriene B₄ in inflammation. Crit Rev Immunol 10 1-12 (1990).

5 McMillan, R.M., and Foster, S.J. Leukotriene B₄ and inflammatory disease. Agents Actions 24 114-119 (1988).

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