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Cat. Number
652889799462772
Chemical Name
JWH 073 4-hydroxyindole metabolite-d7
References
Formal Name (1-​butyl-​(2,​2,​3,​3,​4,​4,​4-​d7)-​4-​hydroxy-​1H-​indol-​3-​yl)(naphthalen-​1-​yl)-​methanone
Molecular Formula C23H14D7NO2
Formula Weight 350.5
Formulation A solution in methanol
Purity ≥99% deuterated product
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES [2H]​C(C(C([2H]​)​([2H]​)​[2H]​)​([2H]​)​[2H]​)​([2H]​)​CN1C2=C(O)​C=CC=C2C(C([2H]​C(C(C([2H]​)​([2H]​)​[2H]​)​([2H]​)​[2H]​)​([2H]​)​CN1C2=CC=CC(O)​=C2C(C(C3=CC=CC4=C3C=CC=C4)​=O)​=C1
Size Global Purchasing
100 µg  
500 µg  
1 mg  
5 mg  

Description

JWH 073 4-hydroxyindole metabolite-d7 contains seven deuterium atoms at the 2, 2’, 3, 3’, 4, 4, and 4 positions. It is intended for use as an internal standard for the quantification of JWH 073 4-hydroxyindole metabolite by GC- or LC-mass spectrometry (MS). JWH 073 is a mildly selective agonist of the central cannabinoid (CB1) receptor derived from the aminoalkylindole WIN 55212-2. The Ki values for binding CB1 and the peripheral cannabinoid (CB2) receptor are 8.9 and 38 nM, respectively for a CB1:CB2 ratio of 0.23.1 JWH 073 is one of several synthetic CBs which have been included in smoking mixtures. JWH 073 4-hydroxyindole metabolite is expected to be a urinary metabolite of JWH 073 based on the metabolism of the closely-related JWH 015 and JWH 018.2,3

1 Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug Alcohol Depend 60 133-140 (2000).

2 Zhang, Q., Ma, P., Cole, R.B., et al. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MS. Anal Bioanal Chem 386 1345-1355 (2006).

3 Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine. Forensic Sci Int 200 141-147 (2010).

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