| References |
| Synonyms |
|
| Formal Name |
4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic-21,21,22,22,22-d5 acid |
| Molecular Formula |
C22H27D5O2 |
| Formula Weight |
333.5 |
| Formulation |
A solution in ethanol |
| Purity |
≥99% deuterated product |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| SMILES |
CC/C=CC/C=CC/C=CC/C=CC/C=CCCCCCC(=O)O
|
Background Reading
Salem, N., Kim, H., and Yergey, J.A. Docosahexaenoic acid: Membrane function and metabolism. 263-317 (1986).
Weisinger, H.S., Armitage, J.A., Sinclair, A.J., et al. Perinatal ω-3 fatty acid deficiency affects blood pressure later in life. Nat Med 7(3) 258-259 (2001).
Hoffman, D.R., Uauy, R., and Birch, D.G. Metabolism of ω-3 fatty acids in patients with autosomal dominant retinitis pigmentosa. Exp Eye Res 60 279-289 (1995).
| Size |
Global Purchasing |
| 50 µg |
|
| 100 µg |
|
| 500 µg |
|
| 1 mg |
|
Description
Docosahexaenoic Acid-d5 (DHA-d5) contains five deuterium atoms at the 21, 21, 22, 22 and 22 positions. It is intended for use as an internal standard for the quantification of DHA by GC- or LC-mass spectrometry. DHA is an essential fatty acid and the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain. DHA constitutes as much as 40% of the total polyunsaturated fatty acid pool in retinal and neuronal membranes.1 Supplementation of dietary DHA using fish oil inhibits the progression of atherosclerosis and delays photoreceptor degeneration in retinitis pigmentosa.2 Neonatal DHA deprivation causes developmental defects and can lead to hypertension in rats.3
1
Salem, N., Kim, H., and Yergey, J.A. Docosahexaenoic acid: Membrane function and metabolism. 263-317 (1986).
2
Hoffman, D.R., Uauy, R., and Birch, D.G. Metabolism of ω-3 fatty acids in patients with autosomal dominant retinitis pigmentosa. Exp Eye Res 60 279-289 (1995).
3
Weisinger, H.S., Armitage, J.A., Sinclair, A.J., et al. Perinatal ω-3 fatty acid deficiency affects blood pressure later in life. Nat Med 7(3) 258-259 (2001).
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