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Cat. Number

652674975247944

Chemical Name

Arachidonoyl Ethanolamide-d8

References

Synonyms	Anandamide-d8 AEA-d8
Formal Name	N-(2-hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide-5,6,8,9,11,12,14,15-d8
Molecular Formula	C₂₂H₂₉D₈NO₂
Formula Weight	355.6
Formulation	A solution in methyl acetate
Purity	≥99% deuterated product
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	CCCCC/C=CC/C=CC/C=CC/C=CCCCC(=O)NCCO

Background Reading

Devane, W.A., Hanus, L., Breuer, A., et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258 1946-1949 (1992).

Felder, C.C., Briley, E.M., Axelrod, J., et al. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. Proc Natl Acad Sci USA 90 7656-7660 (1993).

Size	Global Purchasing
100 µg
500 µg
1 mg
5 mg

Description

Arachidonoyl ethanolamide-d₈ (AEA-8) contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of AEA by GC- or LC-mass spectrometry. AEA is the ethanolamine amide of arachidonic acid, first isolated from porcine brain.¹ It is an endogenous cannabinoid neurotransmitter that binds to both CB₁ and CB₂ receptors.² AEA inhibits the specific binding of [³H]-HU-243 to synaptosomal membranes with a K_i value of 52 nM, compared to 46 nM for Δ⁹-THC.¹

1 Devane, W.A., Hanus, L., Breuer, A., et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258 1946-1949 (1992).

2 Felder, C.C., Briley, E.M., Axelrod, J., et al. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. Proc Natl Acad Sci USA 90 7656-7660 (1993).

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