| References |
| Synonyms |
|
| Molecular Formula |
C20H28D6O2 |
| Formula Weight |
312.5 |
| Formulation |
A solution in methyl acetate |
| Purity |
≥99% deuterated product |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| Size |
Global Purchasing |
| 100 µg |
|
| 500 µg |
|
| 1 mg |
|
| 5 mg |
|
Description
5(Z),8(Z),11(Z)-Eicosatrienoic Acid-d6 contains six deuterium atoms at the 5, 6, 8, 9, 11, and 12 positions. It is intended for use as an internal standard for the quantification of 5(Z),8(Z),11(Z)-eicosatrienoic acid by GC- or LC-mass spectrometry. Eicosatrienoic acid accumulates in the tissues of animals fed diets deficient in both ω-3 and ω-6 fatty acids. It can be converted to 3-series cysteinyl-leukotrienes but cannot serve as a COX substrate.1 The kidneys from essential fatty acid deficient rats are less immunogenic when transplanted, and the metabolites of eicosatrienoic acid are believed to play a role in altering the immune status of these organs.2
1
Lefkowith, J.B. Essential fatty acid deficiency: Probing the role of arachidonate in biology. Adv Prostaglandin Thromboxane Leukot Res 20 224-231 (1990).
2
Schreiner, G.F., Flye, W., Brunt, E., et al. Essential fatty acid depletion of renal allografts and prevention of rejection. Science 240 1032-1033 (1988).
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