| References |
| Formal Name |
5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic-5,6,8,9,11,12,14,15-d8 acid |
| Molecular Formula |
C20H24D8O3 |
| Formula Weight |
328.5 |
| Formulation |
A solution in acetonitrile |
| Purity |
≥99% deuterated product |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| SMILES |
CCCCC/C=CC/C=CC/C=CC=C/CCCCC(=O)O
|
Background Reading
Dodge, W., and Thomas, M. The effect of 5-hydroxyeicosatetraenoic acid on the proliferation of granulocyte progenitors and embryonic fibroblasts of the chick. Biochem Biophys Res Commun 131 731-735 (1985).
Powell, W.S., Gravelle, F., and Gravel, S. Metabolism of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid and other 5(S)-hydroxyeicosanoids by a specific dehydrogenase in human polymorphonuclear leukocytes. J Biol Chem 267 19233-19241 (1992).
Schwenk, U., and Schröder, J. 5-oxo-Eicosanoids are potent eosinophil chemotactic factors. J Biol Chem 270 15029-15036 (1994).
| Size |
Global Purchasing |
| 25 µg |
|
| 50 µg |
|
| 100 µg |
|
| 500 µg |
|
Description
5(S)-HETE-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of 5(S)-HETE by GC- or LC-mass spectrometry (MS). 5(S)-HETE is produced by the action of 5-lipoxygenase on arachidonic acid to give 5(S)-HpETE, followed by reduction of the hydroperoxide. 5(S)-HETE has proliferative and chemotactic effects on granulocytes.1 When further metabolized to the 5-oxoETE, it is a more potent eosinophil chemoattractant than leukotriene B4.2,3
1
Schwenk, U., and Schröder, J. 5-oxo-Eicosanoids are potent eosinophil chemotactic factors. J Biol Chem 270 15029-15036 (1994).
2
Powell, W.S., Gravelle, F., and Gravel, S. Metabolism of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid and other 5(S)-hydroxyeicosanoids by a specific dehydrogenase in human polymorphonuclear leukocytes. J Biol Chem 267 19233-19241 (1992).
3
Dodge, W., and Thomas, M. The effect of 5-hydroxyeicosatetraenoic acid on the proliferation of granulocyte progenitors and embryonic fibroblasts of the chick. Biochem Biophys Res Commun 131 731-735 (1985).
|
