HX 531, RXR拮抗剂_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

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Cat. Number

HB-167342

Chemical Name

HX 531, RXR拮抗剂

CAS Number

188844-34-0

Mol. Formula

C29H29N3O4

Mol. Weight

483.56

Qty 1

10mg

Qty 2

50mg

Application Notes

>98 %

Synonym

4-(7,8,9,10-Tetrahydro-5,7,7,10.10- pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4] -diazepin-12-yl)-benzoic acid

Solubility

Soluble to 100 mM in DMSO

Storage condition

+4°C

References

HX 531是一种有效的维甲酸X受体(RXR)的拮抗剂，IC50值为18 nM，可抑制9-顺式维甲酸诱导的RXR的转激活。它已被证明可以降低高脂肪饮食小鼠的白色脂肪组织、骨骼肌和肝脏中的甘油三酯含量。HX 531是类维生素X受体的拮抗剂。

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产品信息：

CAS RN	188844-34-0
Product Name	4-(5,7,7,10,10-Pentamethyl-2-nitro-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid
Molecular Formula	C29H29N3O4
Molecular Weight	483.6 g/mol
IUPAC Name	4-(5,7,7,10,10-pentamethyl-2-nitro-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid
InChI	InChI=1S/C29H29N3O4/c1-28(2)12-13-29(3,4)22-16-25-20(15-21(22)28)26(17-6-8-18(9-7-17)27(33)34)30-23-14-19(32(35)36)10-11-24(23)31(25)5/h6-11,14-16H,12-13H2,1-5H3,(H,33,34)
InChI Key	SXKPGYKPQPYJER-UHFFFAOYSA-N
SMILES	CC1(CCC(C2=C1C=C3C(=C2)N(C4=C(C=C(C=C4)[N+](=O)[O-])N=C3C5=CC=C(C=C5)C(=O)O)C)(C)C)C
Canonical SMILES	CC1(CCC(C2=C1C=C3C(=C2)N(C4=C(C=C(C=C4)[N+](=O)[O-])N=C3C5=CC=C(C=C5)C(=O)O)C)(C)C)C
Appearance	Solid powder
Purity	>98% (or refer to the Certificate of Analysis)
Shelf Life	>2 years if stored properly
Solubility	Soluble in DMSO
Storage	Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Synonyms	diazepinylbenzoic acid HX531