服务热线
021-60498804
| Cat. Number | 288051274188994 |
| Chemical Name | FK 506 |
| CAS Number | [109581-93-3] |
| Mol. Formula | C44H69NO12 |
| Mol. Weight | 804.02 |
| Qty 1 |
10mg |
| Synonym | (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R ,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25, 26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R ,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methyleth enyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2- propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaa zacyclotricosine-1,7,20,21(4H,23H)tetrone |
| Solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| Storage condition | Store at -20°C |
| References | Potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC50 = 1 nM), IL-3, IL-4, IL-6 (IC50 = 35 nM), GM-CSF, TNFα (IC50 = 10 nM), IFNγ and Myc from activated T-cells in vitro. Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo. Purity: >99 % |
下一个：L-Ascorbic acid上一个：Ascomycin |
|
Copyright © 2022 上海惠诚生物科技有限公司
沪ICP备2021037845号-6
