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| Cat. Number | 288044734331353 |
| Chemical Name | Ascomycin |
| CAS Number | [104987-12-4] |
| Mol. Formula | C43H69NO12 |
| Mol. Weight | 792.01 |
| Qty 1 |
1mg |
| Synonym | (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R ,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,1 9,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E )-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-m ethylethenyl]-14,16-dimethoxy-4,10,12,18-tetrameth yl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotri cosine-1,7,20,21(4H,23H)tetrone |
| Solubility | Soluble to 50 mM in DMSO and to 50 mM in ethanol |
| Storage condition | Store at -20°C |
| References | Analog of FK 506 (Cat. No. 3631); binds to FK 506-binding protein 12 (FKBP12) in order to inhibit calcineurin phosphatase activity (IC50 = 49 nM) and activation of nuclear factor of activated T cells (NFAT). Displays antifungal and immunosuppressive activities. Purity: >99 % |
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