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| Cat. Number | 287770305956728 |
| Chemical Name | API-2 |
| CAS Number | [35943-35-2] |
| Mol. Formula | C13H16N6O4 |
| Mol. Weight | 320.31 |
| Qty 1 |
10mg |
| Synonym | 1,5-Dihydro-5-methyl-1-β-D-ribofuran osyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine |
| Solubility | Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO |
| Storage condition | Store at RT |
| References | Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3β and AFX. Induces apoptosis and growth arrest in vitro, preferentially in human cancer cells with elevated levels of Akt. Potently and selectively inhibits growth of Akt-overexpressing tumors in mice. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2. Purity: >99 % |
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