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| Cat. Number | 287707358564457 |
| Chemical Name | 2-APB |
| CAS Number | [524-95-8] |
| Mol. Formula | C14H16BNO |
| Mol. Weight | 225.1 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 2-Aminoethoxydiphenylborane |
| Solubility | Soluble to 10 mM in ethanol and to 100 mM in DMSO |
| Storage condition | Store at RT |
| References | A functional and membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP3) receptor antagonist (IC50 = 42 μM). Stimulates store-operated calcium (SOC) release at low concentrations (< 10 μM) and inhibits it at higher concentrations (up to 50 μM). Increases STIM-Orai channel conductance and limits ion selectivity. Modulator of TRP channels; blocks TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2 and at higher concentrations stimulates TRPV1, TRPV2 and TRPV3. Also blocks specific gap channel subtypes. Purity: >98 % |
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