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/ Products Classification 点击展开+Cat. Number | 287542796625378 |
Chemical Name | Antisauvagine-30 |
CAS Number | [220673-95-0] |
Mol. Formula | C161H274N48O46S |
Mol. Weight | 3650.29 |
Qty 1 |
1mg |
Storage condition | Desiccate at -20°C |
References | Potent, selective and competitive corticotropin-releasing factor CRF2 receptor antagonist (Kd values are 1.4 and 153.6 nM for binding to mouse CRF2β and rat CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in HEK-mCRF2β cells (pA2 = 8.49). Prevents stress-enhanced fear conditioning and MEK 1/2-dependent activation of ERK1/2 in mice in vivo. |
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