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| Cat. Number | 286656284993614 |
| Chemical Name | AF 12198 |
| CAS Number | [185413-30-3] |
| Mol. Formula | C96H123N19O22 |
| Mol. Weight | 1895.14 |
| Qty 1 |
1mg |
| Storage condition | Desiccate at -20°C |
| References | Potent and selective antagonist for the human type I interleukin-1 (IL-1) receptor (IC50 values are 8 nM, > 6.7 mM and > 200 mM for human type I, human type II and murine type I IL-1 receptors respectively). Blocks IL-1-induced expression of ICAM-1 and E-selectin in HUVECs and IL-1β induction of IL-8 in human dermal fibroblasts. Reduces IL-1β-induced IL-6 production and exhibits anti-inflammatory activity in vivo. |
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