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| Cat. Number | 284743228946286 |
| Chemical Name | BIBU 1361 dihydrochloride |
| CAS Number | [793726-84-8] |
| Mol. Formula | C22H27ClFN7.2HCl |
| Mol. Weight | 516.87 |
| Qty 1 |
1mg |
| Qty 2 | 10mg |
| Synonym | N-(3-Chloro-4-fluorophenyl)-6-[4-[( diethylamino)methyl]-1-piperidinyl]-pyrimido[5,4-d ]pyrimidin-4-amine dihydrochloride |
| Solubility | Soluble to 100 mM in water and to 25 mM in DMSO |
| Storage condition | Desiccate at +4°C |
| References | Potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). Displays ~ 100-fold lower potency against ErbB2 (IC50 = 290 nM) and is selective over a range of other related tyrosine kinases (IC50 > 10 μM). Blocks downstream EGFR signaling events such as MAPKK/MAPK activation. Oral administration inhibits growth of established human xenografts in athymic mice. Purity: >97 % |
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