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Cat. Number
283485305507664
Chemical Name
CP 100356 hydrochloride
CAS Number
[142716-85-6]
Mol. Formula
C31H36N4O6.HCl
Mol. Weight
597.1
Qty 1
10mg
Qty 2
50mg
Synonym
4-(3,4-Dihydro-6,7-dimethoxy-2(1H)- isoquinolinyl)-N-2[2-(3,4-dimethoxyphenyl)ethyl]-6 ,7-dimethoxy-2-quinazolinamine hydrochloride
Solubility
Soluble to 20 mM in DMSO
Storage condition
Desiccate at RT
References
High affinity P-glycoprotein (P-gp) inhibitor (Ki values are 58 and 94 nM for mouse Pgp1a and Pgp1b isoforms). Inhibits calcein-AM uptake in MDR1-transfected MDCKII cells (IC50 = 0.5 μM) and prazosin transport in BCRP-transfected MDCKII cells (IC50 = 1.5 μM). Displays weak or no inhibitory activity against MRP1, OATP1B1 and several major human P450 enzymes (IC50 > 50 μM).
Purity: >98 %
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