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/ Products Classification 点击展开+Cat. Number | 283485305507664 |
Chemical Name | CP 100356 hydrochloride |
CAS Number | [142716-85-6] |
Mol. Formula | C31H36N4O6.HCl |
Mol. Weight | 597.1 |
Qty 1 |
10mg |
Qty 2 | 50mg |
Synonym | 4-(3,4-Dihydro-6,7-dimethoxy-2(1H)- isoquinolinyl)-N-2[2-(3,4-dimethoxyphenyl)ethyl]-6 ,7-dimethoxy-2-quinazolinamine hydrochloride |
Solubility | Soluble to 20 mM in DMSO |
Storage condition | Desiccate at RT |
References | High affinity P-glycoprotein (P-gp) inhibitor (Ki values are 58 and 94 nM for mouse Pgp1a and Pgp1b isoforms). Inhibits calcein-AM uptake in MDR1-transfected MDCKII cells (IC50 = 0.5 μM) and prazosin transport in BCRP-transfected MDCKII cells (IC50 = 1.5 μM). Displays weak or no inhibitory activity against MRP1, OATP1B1 and several major human P450 enzymes (IC50 > 50 μM). Purity: >98 % |
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