服务热线
021-60498804
| Cat. Number | 283177511154506 |
| Chemical Name | Clofarabine |
| CAS Number | [123318-82-1] |
| Mol. Formula | C10H11ClFN5O3 |
| Mol. Weight | 303.68 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 2-Chloro-9-(2-deoxy-2-fluoro-β-D-ara binofuranosyl)-9H-purin-6-amine |
| Solubility | Soluble to 10 mM in water and to 100 mM in DMSO |
| Storage condition | Desiccate at +4°C |
| References | Deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors. Purity: >99 % |
Copyright © 2022 上海惠诚生物科技有限公司
沪ICP备2021037845号-6
