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Cat. Number
278981510750519
Chemical Name
Demethylasterriquinone B1
CAS Number
[78860-34-1]
Mol. Formula
C32H30N2O4
Mol. Weight
506.59
Qty 1
5mg
Synonym
2-[2-(1,1-Dimethyl-2-propenyl)-1H-i ndol-3-yl]-3,6-dihydroxy-5-[7-(3-methyl-2-butenyl) -1H-indol-3-yl]-2,5-cyclohexadiene-1,4-dione
Solubility
Soluble to 100 mM in DMSO
Storage condition
Desiccate at -20°C
References
Selective insulin receptor (IR) activator/mimetic (EC50 values are 3 - 6 μM for IRTK and 100 μM for IGF1R and EGFR). Increases IR β subunit tyrosine phosphorylation and downstream activation of PI 3-kinase and Akt, but not ERK. Induces glucose uptake in adipocytes and skeletal muscle in vitro, without enhancing vascular proliferation. Binds GAPDH.
Purity: >98 %
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