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| Cat. Number | Embelin |
| Chemical Name | Embelin |
| CAS Number | [550-24-3] |
| Mol. Formula | C17H26O4 |
| Mol. Weight | 294.39 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 2,5-Dihydroxy-3-undecyl-2,5-cyclohe xadiene-1,4-dione |
| Solubility | Soluble to 10 mM in ethanol and to 100 mM in DMSO |
| Storage condition | Store at +4°C |
| References | Cell-permeable, non-peptide inhibitor of X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM in competition binding assay with Smac peptide); binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Inhibits cell growth, induces apoptosis and activates caspase-9 in prostate cancer cells (IC50 4 - 6 μM), but has a weaker effect on normal prostate cells (IC50 = 19 - 20 μM). Overcomes the protective effect of XIAP on apoptosis in XIAP-transfected Jurkat cells. Anti-tumor, analgesic and anti-inflammatory in vivo. Purity: >98 % |
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