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Cat. Number
EHT 1864
Chemical Name
EHT 1864
CAS Number
[754240-09-0]
Mol. Formula
C25H27F3N2O4S.2HCl
Mol. Weight
581.47
Qty 1
10mg
Qty 2
50mg
Synonym
5-(5-(7-(Trifluoromethyl)quinolin-4 -ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4 -one dihydrochloride
Solubility
Soluble to 100 mM in water and to 75 mM in DMSO
Storage condition
Store at +4°C
References
Inhibitor of Rac family GTPases. Blocks activation by direct binding to Rac1, Rac1b, Rac2 and Rac3 (KD values are 40, 50, 60 and 250 nM respectively). Inhibits Rac, Ras and Tiam-induced growth transformation of NIH-3T3 fibroblasts. Reduces β-amyloid peptide production in vivo.
Purity: >98 %
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