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| Cat. Number | FTI 277 |
| Chemical Name | FTI 277 |
| CAS Number | [170006-73-2] |
| Mol. Formula | C22H29N3O3S2.C2HF3O2 |
| Mol. Weight | 561.64 |
| Qty 1 |
1mg |
| Synonym | N-[4-[2(R)-Amino-3-mercaptopropyl]a mino-2-phenylbenzoyl]methionine methyl ester trifluoroacetate salt |
| Solubility | Soluble to 5 mM in water |
| Storage condition | Store at -80°C |
| References | Prodrug form of FTI 276 (Cat. No. 2406) that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10 μM respectively) and disrupts constitutive H-Ras-specific actvation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines. Purity: >95 % |
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