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| Cat. Number | FR 180204 |
| Chemical Name | FR 180204 |
| CAS Number | [865362-74-9] |
| Mol. Formula | C18H13N7 |
| Mol. Weight | 327.34 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 5-(2-Phenyl-pyrazolo[1,5-a]pyridin- 3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine |
| Solubility | Soluble to 100 mM in DMSO |
| Storage condition | Store at +4°C |
| References | Selective ERK inhibitor (IC50 values are 0.14 and 0.31 μM for ERK2 and ERK1 respectively). Displays 30-fold selectivity for ERK over p38α (IC50 = 10 μM); displays no activity against human recombinant MEK1, MKK4, IKKα, PKCα, Src, Syc and PDGFα at concentrations less than 30 μM. Also inhibits TGFβ-induced AP-1 activation in Mv1Lu cells (IC50 = 3.1 μM). Purity: >98 % |
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