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| Cat. Number | GW 843682X |
| Chemical Name | GW 843682X |
| CAS Number | [660868-91-7] |
| Mol. Formula | C22H18F3N3O4S |
| Mol. Weight | 477.46 |
| Qty 1 |
1mg |
| Qty 2 | 50mg |
| Synonym | 5-(5,6-Dimethoxy-1H-benzimidazol-1- yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiop henecarboxamide |
| Solubility | Soluble to 75 mM in DMSO and to 5 mM in ethanol |
| Storage condition | Desiccate at +4°C |
| References | Selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC50 values are 2.2 and 9.1 nM respectively). Displays > 100-fold selectivity over ~30 other kinases tested including cdk1 and cdk2. Inhibits proliferation of most tumor cells in vitro and is selective over normal diploid fibroblasts. Purity: >98 % |
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