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| Cat. Number | 2474 |
| Chemical Name | GW 3965 hydrochloride |
| CAS Number | 405911-09-3 |
| Mol. Formula | C33H31NO3ClF3.HCl |
| Mol. Weight | 618.51 |
| Qty 1 |
1mg |
| Qty 2 | 10mg |
| Application Notes | HPLC>98 % |
| Synonym | 3-[3-[[[2-Chloro-3-(trifluoromethyl )phenyl]methyl](2,2-diphenylethyl)amino]propoxy]be nzeneacetic acid hydrochloride |
| Solubility | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| Storage condition | Desiccate at RT |
| References |
Selective, orally active non-steroidal agonist for the liver X receptor (LXR). In cell-based reporter gene assays, acts as a full agonist of hLXRα and hLXRβ (EC50 values are 190 and 30 nM respectively). Reduces angiotensin II-mediated increases in blood pressure; up-regulates ABCA1 gene expression and raises circulating HDL levels. Displays potent antiatherogenic activity in mouse models of atherosclerosis. |
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