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| Cat. Number | GTP 14564 |
| Chemical Name | GTP 14564 |
| CAS Number | [34823-86-4] |
| Mol. Formula | C15H10N2O |
| Mol. Weight | 234.26 |
| Qty 1 |
10mg |
| Synonym | 3-Phenyl-1H-benzofuro[3,2-c]pyrazol e |
| Solubility | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| Storage condition | Store at +4°C |
| References | Potent, selective inhibitor of class III receptor tyrosine kinases (IC50 values are 0.3 μM for c-Fms, c-Kit, FLT3 and ITD-FLT3 and 1 μM for PDGFRβ). Displays no selectivity for ERK1, ERK2, EGFR, MEK1, HER2, Src, Abl, PKC, PKA and Akt (IC50 > 10 μM). Inhibits FL-dependent proliferation in BaF/ITD-FLT3 cells more potently than BaF/wt-FLT3 cells; anti-leukaemic. |
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