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/ Products Classification 点击展开+Cat. Number | LY 341495 |
Chemical Name | LY 341495 |
CAS Number | [201943-63-7] |
Mol. Formula | C20H19NO5 |
Mol. Weight | 353.37 |
Qty 1 |
1mg |
Qty 2 | 50mg |
Synonym | (2S)-2-Amino-2-[(1S,2S)-2-carboxycy cloprop-1-yl]-3-(xanth-9-yl) propanoic acid |
Solubility | Soluble to 10 mM in DMSO and to 100 mM in 1.2eq. NaOH |
Storage condition | Store at RT |
References |
Highly potent and selective group II metabotropic glutamate receptor antagonist (Ki/IC50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGlu2, mGlu3, mGlu8 , mGlu7a, mGlu1a, mGlu5a and mGlu4a receptors respectively). Readily brain penetrant and active in vivo. Also available as part of the Group II mGlu Receptor Tocriset™, Group III mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™. |
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