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| Cat. Number | GF 109203X |
| Chemical Name | GF 109203X |
| CAS Number | [133052-90-1] |
| Mol. Formula | C25H24N4O2 |
| Mol. Weight | 412.49 |
| Qty 1 |
1mg |
| Qty 2 | 10mg |
| Synonym | 2-[1-(3-Dimethylaminopropyl)indol-3 -yl]-3-(indol-3-yl) maleimide |
| Solubility | Soluble to 25 mM in DMSO |
| Storage condition | Store at RT |
| References | Very potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM). Anti-inflammatory in vivo. Also available as part of the Mixed Kinase Inhibitor Tocriset™. Purity: >98 % |
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