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Cat. Number
Gedunin
Chemical Name
Gedunin
CAS Number
[2753-30-2]
Mol. Formula
C28H34O7
Mol. Weight
482.57
Qty 1
10mg
Synonym
(1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12 aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b ,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethylox ireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione
Solubility
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Storage condition
Store at +4°C
References
Naturally occurring Hsp90 inhibitor. Induces Hsp90-dependent client protein degradation and displays antiproliferative activity in vitro (IC50 values are 3.22, 8.84 and 16.8 μM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Also exhibits antimalarial activity against P. falciparum (IC50 values are 0.14 and 3.1 μM in parasite development and [3H]-hypoxanthine uptake assays respectively).
Purity: >98 %
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