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| Cat. Number | HLI 373 |
| Chemical Name | HLI 373 |
| CAS Number | [502137-98-6] |
| Mol. Formula | C18H23N5O2.HCl |
| Mol. Weight | 377.87 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 5-[[3-Dimethylamino)propyl]amino]-3 ,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-d ione dihydrochloride |
| Solubility | Soluble to 100 mM in water and to 10 mM in DMSO |
| Storage condition | Desiccate at RT |
| References | Inhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS. Purity: >99 % |
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