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| Cat. Number | JLK 6 |
| Chemical Name | JLK 6 |
| CAS Number | [62252-26-0] |
| Mol. Formula | C10H8ClNO3 |
| Mol. Weight | 225.63 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 7-Amino-4-chloro-3-methoxy-1H-2-ben zopyran |
| Solubility | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| Storage condition | Store at RT |
| References | Inhibitor of γ-secretase that selectively inhibits βAPP cleavage without affecting other γ-secretase-mediated pathways. Prevents recovery of Aβ40 and Aβ42 from HEK293 cell overexpressing wild-type or Swedish-mutated βAPP (IC50 ~ 30 μM) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α-secretase, the proteosome or GSK3β. Purity: >99 % |
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