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/ Products Classification 点击展开+Cat. Number | LDN 57444 |
Chemical Name | LDN 57444 |
CAS Number | [668467-91-2] |
Mol. Formula | C17H11Cl3N2O3 |
Mol. Weight | 397.64 |
Qty 1 |
10mg |
Qty 2 | 50mg |
Synonym | 5-Chloro-1-[(2,5-dichlorophenyl)met hyl]-1H-indole-2,3-dione 3-(O-acetyloxime) |
Solubility | Soluble to 50 mM in DMSO |
Storage condition | Desiccate at +4°C |
References | Inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity (Ki = 0.4 μM). Causes cell death through the apoptosis pathway; increases levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity. Activity leads to dramatic alterations in synaptic protein distribution and spine morphology in vivo. Purity: >98 % |
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