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Cat. Number
ZM 336372
Chemical Name
ZM 336372
CAS Number
[208260-29-1]
Mol. Formula
C23H23N3O3
Mol. Weight
389.45
Qty 1
10mg
Qty 2
50mg
Synonym
3-(Dimethylamino)-N-[3-[(4-hydroxyb enzoyl)-amino]-4-methylphenyl]benzamide
Solubility
Soluble to 100 mM in DMSO
Storage condition
Store at +4°C
References
Potent, selective inhibitor of c-Raf in vitro (IC50 = 70 nM for inhibition of human c-Raf). Shows 10-fold selectivity over B-Raf. Also inhibits SAPK2/p38 (IC50 = 2 μM). Selective over 17 other protein kinases including PKA, PKC, p42 MAPK, CDK1 and SAPK1/JNK (up to 50 μM). Also available as part of the MAPK Cascade Inhibitor Tocriset™.
Purity: >98 %
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