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Cat. Number
NPS 2143 hydrochloride
Chemical Name
NPS 2143 hydrochloride
CAS Number
[284035-33-2]
Mol. Formula
C24H25ClNO2.HCl
Mol. Weight
445.38
Qty 1
10mg
Qty 2
50mg
Synonym
2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2 -(2-naphthalenyl)ethyl]amino-2-hydroxypropoxy]benz onitrile hydrochloride
Solubility
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Storage condition
Desiccate at RT
References
Selective Ca2+-sensing receptor antagonist. Blocks increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells (IC50 = 43 nM). Also stimulates parathyroid hormone secretion from bovine parathyroid cells (EC50 = 41 nM). Orally active calcilytic compound.
Purity: >99 %
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