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| Cat. Number | N1982 |
| Chemical Name | N1982 NEUROMEDIN U, RAT 117505-80-3 |
| CAS Number | 117505-80-3 |
| Mol. Formula | C124H180N34O31 |
| Mol. Weight | 2643.03 |
| Qty 1 |
1mg |
| Qty 2 | 2mg |
| Application Notes | ≥95% |
| Solubility | Soluble in water (1 mg/mL). |
| Storage condition | -20°C |
| References | Neuromedin U is an endogenous neurohormone involved in maintenance of energy homeostasis. Neuromedin U exhibits anorexigenic, thermogenic, anxiolytic, hypertensive, and pro-inflammatory activities. In seasonal animals, neuromedin U increases core temperature and decreases food intake and body weight; these activities are mediated through activation of Wnt/β-catenin signaling. Neuromedin U exhibits anxiolytic benefit in animals undergoing the elevated plus maze test. Neuromedin U also inhibits gastric acid secretion and increases heart rate and blood pressure. Neuromedin U binds neuromedin receptors in ovarian cells, increasing production of progesterone. Additionally, this hormone upregulates inflammation-related cytokine gene expression in vitro in response to bacterial and viral pathogens. ReferencesHelfer G, Ross AW, Morgan PJ. Neuromedin U partly mimics thyroid stimulating hormone and triggers Wnt/β-Catenin signalling in the photoperiodic response of F344 rats. J Neuroendocrinol. 2013 Oct 24. [Epub ahead of print]. PMID: 24164054. Telegdy G, Adamik A. Anxiolytic action of neuromedin-U and neurotransmitters involved in mice. Regul Pept. 2013 Sep 10;186:137-40. PMID: 23892031. Lin TY, Wu FJ, Lee WY, et al. Ovarian regulation of neuromedin U and its local actions in the ovary, mediated through neuromedin U receptor 2. Am J Physiol Endocrinol Metab. 2013 Apr 15;304(8):E800-9. PMID: 23423171. Rahman AA, Shahid IZ, Pilowsky PM. Differential cardiorespiratory and sympathetic reflex responses to microinjection of neuromedin U in rat rostral ventrolateral medulla. J Pharmacol Exp Ther. 2012 Apr;341(1):213-24. PMID: 22262923. Kono T, Hamasuna S, Korenaga H, et al. The role of neuromedin U during inflammatory response in the common carp. Fish Shellfish Immunol. 2012 Jan;32(1):151-60. PMID: 22122861. 上海惠诚生物科技有限公司自2010年成立以来，一直致力于为客户提供试剂，仪器设备和耗材一站式服务。目前在苏州和南通的研发生产基地，专注于体外诊断蛋白，靶标蛋白，工业用酶和细胞因子的生产和定制，按照GMP标准，为工业客户提供大包装蛋白原料。
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