服务热线
021-60498804
| Cat. Number | O1078 |
| Chemical Name | O1078 OCTREOTIDE ACETATE 79517-01-4 |
| CAS Number | 79517-01-4 |
| Mol. Formula | C49H66N10O10S2 • 2C2H4O2 |
| Mol. Weight | 1139.36 |
| Qty 1 |
1mg |
| Qty 2 | 5mg |
| Appearance | White to off white powder |
| Application Notes | ≥95% |
| Synonym | Sandostatin |
| Solubility | Soluble in methanol. Soluble in water. |
| Storage condition | Desiccate at -20°C |
| References | Octreotide is a somatostatin peptide analog that acts at somatostatin receptors and inhibits the release of growth hormone. Octreotide exhibits anticancer, anti-fibrotic, anti-inflammatory, and immunomodulatory activities. Octreotide inhibits colon cancer cell growth through the suppression of Wnt/β-catenin signaling. Octreotide inhibits hepatic stellate cell proliferation, downregulating the expression of TGF-β, α-SMA, Smad-4a, c-Jun, sp-1, ET-1, and collagen; it is also protective against fibrosis in animal models. Additionally, octreotide inhibits peripheral blood mononuclear cell proliferation, decreasing levels of IL-6, IL-10, and IFN-γ and producing clinical improvements in subjects with systematic lupus erythematous. References Wang S, Bao Z, Liang QM, et al. Octreotide stimulates somatostatin receptor-induced apoptosis of SW480 colon cancer cells by activation of glycogen synthase kinase-3β, A Wnt/β-catenin pathway modulator. Hepatogastroenterology. 2013 Oct;60(127):1639-46. PMID: 24634935. Wang J, Wang L, Song G, et al. The mechanism through which octreotide inhibits hepatic stellate cell activity. Mol Med Rep. 2013 May;7(5):1559-64. PMID: 23525276. Tug T, Kara H, Karaoglu A, et al. The effect of octreotide, an analog of somatostatin, on bleomycin-induced interstitial pulmonary fibrosis in rats. Drug Chem Toxicol. 2013 Apr;36(2):181-6. PMID: 22946449. Zhang Y, Huang W, Li F, et al. Octreotide for the treatment of systemic lupus erythematosus: clinical effects and an in vitro study on its therapeutic mechanism. Lupus. 2011 Oct;20(11):1172-81. PMID: 21979989. 上海惠诚生物科技有限公司自2010年成立以来，一直致力于为客户提供试剂，仪器设备和耗材一站式服务。目前在苏州和南通的研发生产基地，专注于体外诊断蛋白，靶标蛋白，工业用酶和细胞因子的生产和定制，按照GMP标准，为工业客户提供大包装蛋白原料。
更多产品请联系惠诚生物！ 蛋白原料网站：www.acediag.com 全国统一服务热线：021- 60496554 24小时手机服务: 13917250134（同微信）QQ：1715451510 Email：info@e-biochem.com |
下一个：NEUROMEDIN U, RAT上一个：PSB 603 |
|
Copyright © 2022 上海惠诚生物科技有限公司
沪ICP备2021037845号-6
