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Cat. Number
Purvalanol B
Chemical Name
Purvalanol B
CAS Number
[212844-54-7]
Mol. Formula
C20H25ClN6O3
Mol. Weight
432.91
Qty 1
10mg
Qty 2
50mg
Synonym
(2R)-2-[[6-[(3-Chloro-4-carboxyphen yl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3 -methyl-1-butanol
Solubility
Soluble to 100 mM in 1eq. NaOH
Storage condition
Store at +4°C
References
Cyclin-dependent kinase inhibitor. IC50 values are 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Selective over a range of other protein kinases (IC50 > 10,000 nM). Shown to have antiproliferative properties, mediated by p42/p44 MAPK.
Purity: >99 %
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