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Cat. Number
PG 01
Chemical Name
PG 01
CAS Number
[853138-65-5]
Mol. Formula
C28H29N3O2
Mol. Weight
439.55
Qty 1
10mg
Qty 2
50mg
Synonym
N-Methyl-N-[2-[[4-(1-Methylethyl)ph enyl]amino]-2-1H-indole-3-acetamide
Solubility
Soluble to 100 mM in DMSO
Storage condition
Store at -20°C
References
Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. Corrects gating defects of CFTR mutants such as ΔF508 (Ka = 0.3 μM), E193K and G970R (Kd values are 0.22 μM and 0.45 μM respectively). Increases ΔF508-CFTR Cl- currents in the presence of forskolin; displays no effect on Ca2+-activated Cl- current.
Purity: >98 %
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