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| Cat. Number | PD 166285 dihydrochloride |
| Chemical Name | PD 166285 dihydrochloride |
| CAS Number | [212391-63-4] |
| Mol. Formula | C25H27Cl2N5O2.2HCl |
| Mol. Weight | 585.35 |
| Qty 1 |
1mg |
| Qty 2 | 10mg |
| Synonym | 6-(2,6-Dichlorophenyl)-2-[[4-[2-(di ethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3 -d]pyrimidin-7(8H)-one dihydrochloride |
| Solubility | Soluble to 100 mM in DMSO |
| Storage condition | Desiccate at RT |
| References | Potent inhibitor of the tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β (PDGFRβ) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). Also inhibits the checkpoint kinases Wee1 and Myt1; abolishes Cdc2 phosphorylation in numerous tumor cell lines and abrogates the G2 checkpoint. Purity: >99 % |
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