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Cat. Number
PD 146176
Chemical Name
PD 146176
CAS Number
[4079-26-9]
Mol. Formula
C15H11NS
Mol. Weight
237.32
Qty 1
10mg
Qty 2
50mg
Synonym
6,11-Dihydro[1]benzothiopyrano[4,3- b]indole
Solubility
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Storage condition
Store at +4°C
References
Specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC50 = 0.54 μM for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment in vivo.
Purity: >98 %
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