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| Cat. Number | PD 0325901 |
| Chemical Name | PD 0325901 |
| CAS Number | [391210-10-9] |
| Mol. Formula | C16H14F3IN2O4 |
| Mol. Weight | 482.19 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | N-[(2R)-2,3-Dihydroxypropoxy]-3,4-d ifluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide |
| Solubility | Soluble to 100 mM in DMSO |
| Storage condition | Store at -20°C |
| References | Selective MEK1 and MEK2 inhibitor. Inhibits MEK activity in mouse colon 26 cells (IC50 = 0.33 nM). Inhibits the growth of melanoma cell lines in vitro and in vivo; induces G1-phase cell cycle arrest and apoptosis in a mouse xenograft model. Also inhibits production of proangiogenic cytokines such as VEGF. Orally active. Purity: >99 % |
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