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| Cat. Number | SCIO 469 hydrochloride |
| Chemical Name | SCIO 469 hydrochloride |
| CAS Number | [309913-83-5] |
| Mol. Formula | C27H30ClFN4O3.HCl |
| Mol. Weight | 549.46 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 6-Chloro-5-[[(2R,5S)-4-[(4-fluoroph enyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]- N,N,1-trimethyl-α-oxo-1H-Indole-3-acetamide hydrochloride |
| Solubility | Soluble to 10 mM in water and to 100 mM in DMSO |
| Storage condition | Desiccate at +4°C |
| References | Selective, ATP-competitive p38 inhibitor (IC50 = 9 nM for p38α in vitro). Displays approximately 10-fold selectivity for p38α over p38β and 2000-fold selectivity for p38α over 20 other kinases. Reduces p38α phosphorylation in multiple myeloma cells in vitro and in vivo; activity results in decreased tumor burden and angiogenesis in murine models of multiple myeloma. Also enhances bortezomib-induced cytotoxicity against multiple myeloma cells. Purity: >98 % |
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