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| Cat. Number | SB 271046 hydrochloride |
| Chemical Name | SB 271046 hydrochloride |
| CAS Number | [209481-20-9] |
| Mol. Formula | C20H22CIN3O3S2.HCl |
| Mol. Weight | 488.45 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 5-Chloro-N-[4-methoxy-3-(1-piperazi nyl)phenyl]-3-methyl-benzo[b]thiophen-2-sulfonamid e hydrochloride |
| Solubility | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| Storage condition | Desiccate at RT |
| References | Orally active, selective 5-HT6 antagonist (pKi values are 9.02-8.92, 6.55, 6.35, 6.27, 6.05, 5.95, 5.76, 5.73, 5.62, 5.55, 5.41, 5.39, 5.27 and < 4.99 at 5-HT6, 5-HT1D, 5-HT1A, D3, 5-HT1B, 5-HT1F, α1B, 5-HT2C, 5-HT2A, D2, 5-HT2B, 5-HT7, 5-HT4 and 5-HT1E respectively) and is > 200-fold selective over 55 other receptors, enzymes and ion channels. Increases extracellular glutamate and aspartate in the frontal cortex, and exhibits anticonvulsant activity (EC50 = 0.16 μM). Purity: >99 % |
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