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| Cat. Number | SB 225002 |
| Chemical Name | SB 225002 |
| CAS Number | [182498-32-4] |
| Mol. Formula | C13H10BrN3O4 |
| Mol. Weight | 352.14 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | N-(2-Bromophenyl)-N'-(2-hydroxy-4-ni trophenyl)urea |
| Solubility | Soluble to 100 mM in DMSO and to 75 mM in ethanol |
| Storage condition | Store at RT |
| References | Potent and selective CXCR2 chemokine receptor antagonist (IC50 = 22 nM) that displays > 150-fold selectivity over CXCR1 receptors. Causes inhibition of IL-8 and GROα-mediated calcium mobilization in HL60 cells (IC50 values are 8 and 10 nM respectively). Prevents IL-8-induced neutrophil chemotaxis in vitro and sequestration in vivo. Inhibits HIV replication in lymphocytes and macrophages. Purity: >99 % |
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