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/ Products Classification 点击展开+Cat. Number | Sazetidine A dihydrochloride |
Chemical Name | Sazetidine A dihydrochloride |
CAS Number | [820231-95-6] |
Mol. Formula | C15H22Cl2N2O2 |
Mol. Weight | 333.25 |
Qty 1 |
10mg |
Synonym | 6-[5-[(2S)-2-Azetidinylmethoxy]-3-p yridinyl]-5-hexyn-1-ol dihydrochloride |
Solubility | Soluble to 50 mM in water |
Storage condition | Desiccate at +4°C |
References | Subtype-selective α4β2 nicotinic acetylcholine receptor ligand (Ki values are 0.26 and 54 nM at α4β2 and α3β4 receptors respectively). May act as a silent desensitizer or as an agonist (EC50 = 1.1 nM for nAChR-stimulated dopamine release). Exhibits analgesic activity in vivo and significantly reduces nicotine self-administration in an experimental rat model. Purity: >98 % |