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Cat. Number
Sazetidine A dihydrochloride
Chemical Name
Sazetidine A dihydrochloride
CAS Number
[820231-95-6]
Mol. Formula
C15H22Cl2N2O2
Mol. Weight
333.25
Qty 1
10mg
Synonym
6-[5-[(2S)-2-Azetidinylmethoxy]-3-p yridinyl]-5-hexyn-1-ol dihydrochloride
Solubility
Soluble to 50 mM in water
Storage condition
Desiccate at +4°C
References
Subtype-selective α4β2 nicotinic acetylcholine receptor ligand (Ki values are 0.26 and 54 nM at α4β2 and α3β4 receptors respectively). May act as a silent desensitizer or as an agonist (EC50 = 1.1 nM for nAChR-stimulated dopamine release). Exhibits analgesic activity in vivo and significantly reduces nicotine self-administration in an experimental rat model.
Purity: >98 %
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